NAD+ Nasal Spray — Safety Information

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every living cell and plays an essential role in energy metabolism and cellular repair. NAD+ nasal spray is a compounded prescription medication designed for intranasal administration under the supervision of a licensed clinician. While NAD+ is not an FDA-approved drug product for nasal delivery, it may be prescribed off-label for certain clinical purposes, as determined appropriate by a healthcare provider.

Important Safety Information

• Use this medication only as prescribed by your licensed clinician.
  
  
• Do not share your medication with others.
  
  
• Report any side effects to your healthcare provider or pharmacist.
  
  
• Seek medical attention immediately if you experience:
  
  
  
  • Chest pain or irregular heartbeat
    
    
  • Shortness of breath or difficulty breathing
    
    
  • Rash, itching, swelling, or hives
    
    
  • Severe dizziness, headache, or confusion
    
    
  • Persistent nausea, vomiting, or abdominal pain
    
    
• Mild nasal irritation, dryness, or temporary flushing may occur.
  
  
• Compounded nasal sprays carry a small risk of contamination if not prepared or stored properly. Always verify your medication is dispensed from a licensed, compliant pharmacy.
  
  

Consult Your Healthcare Provider

Always inform your primary care provider and all other healthcare professionals about every prescription, over-the-counter medication, and supplement you take.
This helps prevent drug interactions and ensures safe, coordinated care.

Warnings and Precautions

• Do not use if you have a known allergy to nicotinamide, niacin, or any ingredient in the formulation.
  
  
• Use caution if you have liver disease, gallbladder issues, or gout, as nicotinamide compounds may affect these conditions.
  
  
• The safety of NAD+ nasal spray in pregnancy or breastfeeding has not been established; use only under medical supervision.
  
  
• Avoid driving or operating machinery if dizziness or fatigue occurs.
  
  
• Use only as directed by your prescribing clinician.
  
  

Drug Interactions

• Niacin, niacinamide, or vitamin B3 supplements may increase overall nicotinamide exposure.
  
  
• Blood pressure medications or vasodilators may enhance flushing or lightheadedness.
  
  
• Antidiabetic drugs may interact with NAD+ metabolism; monitor glucose levels as advised.
  
  
• Provide your clinician with a complete list of all medications, vitamins, and supplements before beginning NAD+ nasal spray.
  
  

Use and Administration

• Administer intranasally as directed by your clinician.
  
  
• Follow the prescribed dosing schedule; do not exceed recommended use.
  
  
• Prime the nasal spray bottle before first use and ensure proper storage between doses.
  
  
• Store at controlled room temperature or refrigerated, as indicated on your prescription label.
  
  
• Keep out of reach of children.
  
  

FDA and Compounding Disclaimer

Some medications offered through our platform may include compounded products that have not been approved by the U.S. Food and Drug Administration (FDA). The FDA does not verify the safety or effectiveness of compounded drugs, including NAD+ Nasal Spray. Our specialists may prescribe this medication off-label from its originally approved use based on clinical judgment and patient need.

Last Updated: October 7, 2025

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