NAD+ Injection — Safety Information

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every living cell and plays a key role in energy metabolism and cellular repair. Injectable NAD+ is a compounded prescription medication designed for intramuscular (IM) or subcutaneous (SubQ) administration under the supervision of a licensed clinician. It is used in certain clinical settings where additional metabolic or mitochondrial support is desired, as determined appropriate by a healthcare provider.

Important Safety Information

• Use only as prescribed by your licensed clinician.
  
  
• Do not share this medication with others.
  
  
• Report any side effects to your clinician or pharmacist.
  
  
• Seek medical attention immediately if you experience:
  
  
  
  • Chest pain or irregular heartbeat
    
    
  • Shortness of breath or severe dizziness
    
    
  • Rash, itching, swelling, or hives
    
    
  • Nausea, vomiting, or severe abdominal pain
    
    
  • Persistent headache or flushing that worsens after injection
    
    
• This medication may cause mild, temporary warmth, flushing, or tingling at the injection site.
  
  
• Compounded sterile injectables carry a small risk of contamination if not properly prepared or stored. Always verify that your medication is dispensed from a licensed and compliant pharmacy.
  
  

Consult Your Healthcare Provider

Always inform your primary care provider and all other healthcare professionals about every prescription, over-the-counter medication, and supplement you take. This helps prevent drug interactions and ensures coordinated, safe care.

Warnings and Precautions

• Do not use if you have a known allergy or sensitivity to nicotinamide, niacin, or any ingredient in the formulation.
  
  
• Use caution if you have liver disease, gallbladder problems, or gout, as high doses of niacin-related compounds can affect these conditions.
  
  
• Safety in pregnancy and breastfeeding has not been firmly established; use only if clearly needed and under medical supervision.
  
  
• Injection should be administered only under clinician guidance using sterile technique.
  
  

Drug Interactions

• Niacin, niacinamide, or vitamin B3 supplements may increase overall nicotinamide exposure.
  
  
• Antihypertensive medications or vasodilators may enhance flushing or blood pressure effects.
  
  
• Antidiabetic drugs may interact with NAD+ metabolism; monitor glucose levels as directed by your provider.
  
  
• Provide your clinician with a complete list of all medications, vitamins, and supplements before starting NAD+ injections.
  
  

Use and Administration

• Administer by intramuscular (IM) or subcutaneous (SubQ) injection as directed by your clinician.
  
  
• Do not adjust your dose or frequency without medical approval.
  
  
• Store according to your prescription label — typically refrigerated and protected from light.
  
  
• Do not freeze.
  
  
• Keep out of reach of children.
  
  

FDA and Compounding Disclaimer

Some medications offered through our platform may include compounded products that have not been approved by the U.S. Food and Drug Administration (FDA).  The FDA does not verify the safety or effectiveness of compounded drugs, including NAD+ Injection. Our specialists may prescribe this medication off-label from its originally approved use based on clinical judgment and patient need.

Last Updated: October 7, 2025

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